Endocrine Abstracts

Context: Perturbations in thyroid function are common in older people, and subclinical hyperthyroidism has been associated with increased risk of dementia in people aged 55 years and above. The significance of subtle perturbations of thyroid function in the very old remains poorly understood.Objective: This study sought to determine if subtle abnormalities of thyrotropin and variations of free thyroid hormones within the reference range correlate with co...

Perturbations in thyroid function are common in older individuals but their significance in the very old is not fully understood. We examined thyroid hormone status (serum TSH, FT4, FT3, rT3) at baseline in a cohort of 643 85-year-olds and followed their mortality and disability outcomes for 9 years. All cause mortality, cardiovascular mortality and disability according to categorical thyroid disease status and baseline thyroid hormone paramete...